LiverPool™ Cryoplateable Human Hepatocytes

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BioreclamationIVT – The complete resource for all biologicals - BioreclamationIVT is the complete resource for all biologicals including human clinical samples, hepatocytes, subcellular fractions and biological matrices.

http://www.bioreclamationivt.com/IN/india_home BioreclamationIVT India PVT Ltd | BioreclamationIVT - BioreclamationIVT now has a presence in Bangalore, India. We are a worldwide provider of biological and in vitro products to pharmaceutical and biotechnology organizations. Our company specializes in control and disease state biological matrices (Whole Blood, Serum, Plasma, CSF, Bile, Milk, Urine, and Tissues) for use in drug discovery along with hepatocyte, microsome and S9 products used in the preclinical industry.

http://www.bioreclamationivt.com/about About | BioreclamationIVT - BioreclamationIVT is the worldwide leader of biological products to life sciences and pharmaceutical companies.

http://www.bioreclamationivt.com/company-profile Company Profile | BioreclamationIVT - BioreclamationIVT is a worldwide provider of biological products to life sciences and pharmaceutical companies

http://www.bioreclamationivt.com/upcoming-events Upcoming Events | BioreclamationIVT - BioreclamationIVT will attend the following scientific meetings. We hope to see you there!

http://www.bioreclamationivt.com/quality-assurance Quality Assurance | BioreclamationIVT - BioreclamationIVT is committed to providing high quality human and animal biological products, processing services, and world-class customer service.

http://www.bioreclamationivt.com/client-testimonials Client Testimonials | BioreclamationIVT - BioreclamationIVT Client Testimonials from some of our many satisfied customers.

http://www.bioreclamationivt.com/locations Locations | BioreclamationIVT - BioreclamationIVT has office locations in North America and Europe and authorized distributors in Asia.

http://www.bioreclamationivt.com/products Products | BioreclamationIVT - BioreclamationIVT is your One Resource for a complete range of animal and human biological tools needed to pursue new drug discovery and development.

http://www.bioreclamationivt.com/normal-human-animal-matrices Normal Human & Animal Matrices | BioreclamationIVT - Normal Human & Animal Matrices BioreclamationIVT has been offering a wide range of normal human and animal biological matrices for over twenty years. Our product offering surpasses anything offered in the market today. Our products are not only readily available but customized to your specifications.

http://www.bioreclamationivt.com/human-animal-matrices/blood-products Blood Products | BioreclamationIVT - Normal Human Blood Products Normal human blood products are collected from consented donors under IRB approved protocols at facilities located in the United States, using BioreclamationIVT Standard Operating Procedures. This allows us to customize every order according to your exact specifications, while maintaining the highest level of product quality. BioreclamationIVT can collect samples that meet your study requirements. Inclusion and/or exclusion criteria can be specified such as: age, gender, weight, ethnicity, smoking status, etc. Specific questions can also be added to the case report form for further screening. BioreclamationIVT provides viral negative normal human samples as noted on the Certificate of Analysis included with each shipment. Samples are tested in accordance with FDA regulations and found negative for HBsAG, HIV 1/2 Ab, HCV Ab, HIV-1 RNA, HCV RNA and STS. Animal Blood Products Animal blood products are collected at facilities located in the United States, using BioreclamationIVT Standard Operating Procedures. This allows us to customize every order according to your exact specifications, while maintaining the highest level of product quality. BioreclamationIVT can collect samples that meet your study requirements and protocol. Inclusion and/or exclusion criteria can be specified.

http://www.bioreclamationivt.com/human-animal-matrices/other-matrices Other Matrices | BioreclamationIVT - BioreclamationIVT provides various types of matrices from human and animal species. The human samples are collected from consented donors at IRB approved facilities located in the United States. The animal samples are collected at facilities located in the United States. Both collections follow BioreclamationIVT Standard Operating Procedures. This allows us to customize every order according to your exact specifications, while maintaining the highest level of product quality. The list of matrices that is provided is not all inclusive. Our large network of sites provides us with limitless options when procuring other fluid type matrices. Amniotic Fluid Feces Sputum Aqueous Humor Gastric Fluid Synovial Fluid (lavage) Bile Hair Tears Bone Marrow Nasal Swabs Throat Swabs Breast Milk Nasal Swabs Urine Bronchial Lavage Saliva Vaginal Fluid Cerebrospinal Fluid Semen Vitreous Humor

http://www.bioreclamationivt.com/human-animal-matrices/custom-collections Custom Collections | BioreclamationIVT - BioreclamationIVT receives requests for the following types of samples. If there is something in particular you require that you cannot find please contact Customer Service. Reproductive Samples - Maternal and Fetal Serum Plasma Whole Blood Amniotic Fluid Breast Milk Tissues & Homogenate Ocular Dissections Aqueous Humor Choroid Cornea Iris Ciliary Body Lens Retina Vitreous Humor

http://www.bioreclamationivt.com/human-animal-matrices/normal-human-animal-tissues Normal Human & Animal Tissues | BioreclamationIVT - BioreclamationIVT provides various types of tissues from human and animal species. The human tissues are collected from consented donors at IRB approved facilities located in the United States. The animal samples are collected at facilities located in the United States. Both collections follow BioreclamationIVT Standard Operating Procedures. BioreclamationIVT can procure a variety of tissues types. Human tissues can be secured and processed from various donor types. Examples include skin punch biopsies and skin from Abdominoplasty in a clinic setting or organ tissues from cadaver donors. The list of tissue types and species that is provided is not all inclusive. Our large network of sites provides us with limitless options when procuring other fluid type matrices. Tissues can be provided in the following formats Fresh Flash Frozen Cadaver Tissue Homogenate Customized preparations

http://www.bioreclamationivt.com/disease-state-tissues Disease State Tissues | BioreclamationIVT - BioreclamationIVT has a worldwide network of hospitals working exclusively to procure high quality biological samples for our onsite tissue bank. Our dynamic network of hospital procurement sites makes BioreclamationIVT unique in the biobanking industry and allows BioreclamationIVT to offer our clients many hard to procure treatment naive tissue specimens in several formats. Standard protocols are used to maintain the BioreclamationIVT repository and adhere to the highest standards of sample integrity, including difficult to procure treatment naïve tumor samples. Standard tissue products are generally available for next day shipping to keep your research moving. We also offer customized tissue collections to customer supplied protocols and specifications. BioreclamationIVT collects every sample under IRB approved protocols, ensuring that strict ethical guidelines are followed to protect patient confidentiality and safety. Each sample has the patients consent for use in a wide range of research including the development of commercial products or services. The samples are identifiable only by barcodes to ensure an unbiased assessment as well as patient confidentiality. BioreclamationIVT also utilizes strict collection protocols. BioreclamationIVT establishes the parameters for time from surgical extraction to snap freezing. This ensures that the tissue specimens are viable with high RIN for the most demanding genomic and proteomic research. All specimens come with complete Clinical, Surgical, and Pathological reports and most have microphotos available for review.

http://www.bioreclamationivt.com/disease-state-tissues/custom-collections Custom Collections | BioreclamationIVT - Custom collections consist of specimens procured according to client defined requirements that deviate from the standard collection procedures. This type of request can provide alternate specimen formats and alternate preservation methods. Examples of previous collections include: PAP smears, fresh or frozen Fresh whole organs Whole placenta, umbilical cord and amniotic fluid Urine, sputum, fluid aspirates DMSO cryopreservation for Cell Culture OCT Embedding with cryoprotection Custom Collections may also consist of additional testing, data collection, client specified specimen collection procedures, and post-collection processing into derivative products. Please inquire for feasibility and time frame as each custom project is unique.

http://www.bioreclamationivt.com/disease-state-tissues/diseased-rna-dna Diseased RNA & DNA | BioreclamationIVT - BioreclamationIVT provides a wide range of molecular extractions for genomic research including DNA extraction (genomic DNA) and RNA extraction (total RNA and mRNA). Standard protocols can be used to obtain genomic DNA and total RNA. A wide range of commercially available DNA extraction and RNA extraction kits or custom protocols can be utilized to obtain samples for specific projects. Each RNA extraction is analyzed on an Agilent 2100 and provided with a quality control report featuring an RNA Integrity Number (RIN). The Agilent 2100 software assigns an integrity number (0-10) to an RNA sample. The Agilent 2100 identifies the presence or absence of degradation of products and interprets the quality of the specimen. DNA quality is analyzed by gel electrophoresis. Quantitation it performed by spectrophotometry (Nanodrop) and fluorometry (Qubit). Careful qualitative and quantitative analysis will guarantee high quality specimens and yield high quality research results. Protein Lysates are extracted using a Modified RIPA Buffer protocol. Lysates can be custom produced from BioreclamationIVT’s tissues.

http://www.bioreclamationivt.com/disease-state-tissues/tissue-microarray Tissue Microarray | BioreclamationIVT - Manufacture of Custom Tissue Microarrays (TMA) can be performed using BioreclamationIVT's high-quality tissues. Standard configuration for a Tumor Matched Pair TMA consists of two tumor cores and one NAT core for each case. Duplication of the tumor core prevents drop out due to layers of fibrous, normal, or necrotic tissue in the sample, ensuring every section is representative of the tumor. Custom configurations can be performed as well. All tissues to be used for a TMA are prescreened using a top slide to identify the areas of the highest tumor cell percentage. Tissue microarrays allow a researcher to process and analyze all of their samples at one time. This greatly accelerates the time to results while reducing the reagents needed to run an assay. The short time frame to results also reduces inter-assay or inter-observer variability.

http://www.bioreclamationivt.com/disease-state-matrices Disease State Matrices | BioreclamationIVT - BioreclamationIVT has an existing clinical sample bank and is also able to perform customized collections for our IRB approved physician sites.

http://www.bioreclamationivt.com/disease-state-matrices/patient-populations Patient Populations | BioreclamationIVT - BioreclamationIVT has a large network of clinical sites from which they can collect disease state material. The patient populations that have been requested are listed below. Oncology | Hematology Leukemias Lymphomas Carcinomas Solid Tumor | Metastatic Autoimmune | Rheumatology Crohn’s Disease Fibromyalgia Gout Inflammatory Bowel Disease Lupus Nephritis Multiple Sclerosis Osteoarthritis Osteoporosis Polymyositis Psoriasis Psoriatic Arthritis Rheumatoid Arthritis Scleroderma Sjogrens Syndrome Systemic Lupus Erythematosus Ulcerative Colitis Cardiovascular Atrial Fibrillation Atherosclerosis Congestive Heart Failure Coronary Disease High Cholesterol Hypertension Dermatology Atopic Dermatitis (Eczema) Melanoma Psoriasis Skin Cancer Endocrinology Type I & II Diabetes Diabetic Neuropathy Growth Hormone Deficiency Gastroenterology Celiac Disease Crohn’s Disease Gastroesophageal Reflux Disease Irritable Bowel Syndrome Infectious Disease Hepatitis HIV Influenza Nephrology Chronic Kidney Disease End Stage Renal Disease Neurology Alzheimer’s Disease Amyotropic Lateral Sclerosis Dementia Multiple Sclerosis Parkinson’s Disease Opthalmology Wet & Dry AMD Retinal Vein Occlusion Retinopathy Pulmonary Allergy Asthma COPD Cystic Fibrosis Pneumonia Normal Controls Pediatric Normals Adult & Elderly Normals Vaccine Recipients Pregnancy Donors Please note these lists are not all inclusive. Please contact us if your study requires other sample types.

http://www.bioreclamationivt.com/disease-state-matrices/products Products | BioreclamationIVT - Below is just sampling of the kind of matrices that BioreclamationIVT offers. Contact Customer Service if there something you are looking for that is not on this list. Our network site is extensive and in most cases we can find the sample required for your research. Matrix Type: Serum Bronchial Lavage Plasma Saliva Whole Blood Milk PBMCs Nasal & Throat Swabs Cerebrospinal Fluid Nasal Wash Urine Biopsy Tissues Sputum Bone Marrow BioreclamationIVT can collect IRB approved delinked remnant specimens according to matrix type, as well as lab results: RF / CRP / dsDNA ALT / AST D-Dimer Growth Hormone Creatinine Toxoplasma Sepsis HIV / HBV / HCV AFP Bilirubin Total Protein Amylase Troponin Glucose CKMB Lipid Values PSA / CA 125 / CA 19-9 Creatinine Free & Total T3 / T4 IgE / IgG PTH TSH Cholesterol / HDL/ LDL Sex Hormone Binding Globulin Please note these lists are not all inclusive.

http://www.bioreclamationivt.com/disease-state-matrices/customization Customization | BioreclamationIVT - BioreclamationIVT prides itself in being able to customize a customer's request. Every customer has a specific requirement for their samples and below is just a sampling of the customization offered. Patient inclusion/exclusion criteria BioreclamationIVT can prospectively collect patient samples that meet your study requirements. Inclusion and/or exclusion criteria can be specified such as age, gender, disease stage, treatments, etc. Longitudinal studies BioreclamationIVT can collect samples from the same donor at multiple time points. Matched Sets BioreclamationIVT can collect multiple matrices from a single donor. Processing / Labeling Customized processing at time of collection. Aliquot into any volume. Barcoded labels can be customized and include client provided id numbers. Anticoagulants / Vacutainers Both blood and plasma samples can be collected with the anticoagulant of your choice and the use of specific vacutainers can be requested.

http://www.bioreclamationivt.com/disease-state-matrices/services-lab-tests Services & Lab Tests | BioreclamationIVT - BioreclamationIVT offers the following additional services for Normal and Clinical Samples: Specimen data provided electronically PBMC isolations (Ficoll Gradient) Flow cytometry Cell counting Leukopaks Buffy coats Human tissue sourcing Diagnostic testing on samples We can perform any available laboratory test on our material or samples to help you utilize our product in a more cost effective manner. Some commonly requested tests are: Standard Chemical Profile Total Protein pH HCG value PSA value Cholesterol & Triglycerides You may request a test to be performed on material you are ordering, or, you can order samples from specific value ranges that meet your criteria. For example, if you need hyperlipidemic material with Triglycerides and Cholesterol values above 250 mg/dL, we will collect and test samples, and only ship the material meeting your requirements. Please note these lists are not all inclusive. Please contact us if your study requires other sample types.

http://www.bioreclamationivt.com/hepatocytes-microsomes-s9 Hepatocytes, Microsomes & S9 | BioreclamationIVT - BioreclamationIVT is a leading provider of human and animal hepatocyte and microsome products for over 20 years. We offer high quality reproducible lots to our customers. All catalog products are readily available for shipment next day. There is a wide range of animal species available across the product lines and those items that are not listed can be made as a custom request by filling out the Request A Quote form. BioreclamationIVT offers the largest human and animal hepatocyte lots in the industry. Check out the Characterization Table for current offerings. Human Hepatocytes LiverPool™ Cryoplateable Human Hepatocytes LiverPool™ Human Hepatocytes Cryoplateable Human Hepatocytes Cryosuspension Human Hepatocytes Fresh Human Hepatocytes Human Subcellular Fractions InVitroCYP™ 150-Donor Human Liver Microsomes InVitroCYP™ H- and M-Class Human Liver Microsomes Human Microsomes – Other Organs Human Liver S9 Animal Hepatocytes Cryoplateable Animal Hepatocytes Cryosuspension Animal Hepatocytes Fresh Animal Hepatocytes Animal Subcellular Fractions Animal Liver Microsomes & S9 Induced Sprague-Dawley Rat Liver Microsomes & S9

http://www.bioreclamationivt.com/hepatocytes-microsomes-s9-hepatocytes/liverpool%E2%84%A2-pooled-human-hepatocytes LiverPool™ Pooled Human Hepatocytes | BioreclamationIVT - Our patented LiverPool™ pooled human hepatocytes are designed exclusively to have the characterization, quality and viability you need for your research.

http://www.bioreclamationivt.com/hepatocytes-microsomes-s9-hepatocytes/liverpool%E2%84%A2-cryoplateable-human-hepatocytes LiverPool™ Cryoplateable Human Hepatocytes | BioreclamationIVT - Hepatocytes from BioreclamationIVT are cryopreserved the same day they are isolated, and come with full serology reporting for your safety. LiverPool cryoplateable human hepatocytes are used for long term studies (≥4 hours) like induction, toxicity, and transport. More recently, scientists also have been using cryoplateable hepatocytes to study transporter uptake, viral transduction and gene induction. BioreclamationIVT's LiverPool cryoplateable human hepatocytes have high levels of induction following treatment with known inducers omeprazole (CYP1A2), phenobarbital (CYP2B6), and rifampin (CYP3A4). All plateable lots have greater than 70% viability and greater than 70% confluence on day 5. Cells are also treated with CDFDA fluorescent dye to show bile caniculi formation. The process for producing the LiverPool™ pooled human hepatocyte products is covered by one or more U.S. or foreign patents and patent applications, including U.S. Patent No. 7,604,929.

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